PO-05-021 HYPERTROPHIC CARDIOMYOPATHY INCREASES THE RISKS OF BRADYARRHYTHMIA AND PACEMAKER IMPLANTATION

Previous studies of bradycardia complicating hypertrophic cardiomyopathy (HCM) have been reported in rare patients. Whether HCM is associated with bradyarrhythmia, leading to permanent pacemaker (PPM) implantations, remains unclear. We aimed explore the risks bradyarrhythmia and subsequent PPM implantation patients HCM. Patients newly diagnosed were identified from Taiwan National Health Insurance Research Database 2012 2017. A control cohort was selected by matching age gender a 1:1 ratio study (Panel A). The primary outcomes occurrence bradyarrythmia or implantation. multivariate Cox hazards regression model used evaluate hazard (HR) for outcomes. total 12,094 (n=6,047 each group) mean 63.1±14.8 years analyzed. During follow-up period 3.17±1.77 years, percentage higher group (3.3%) than that (0.5%) (p<0.001). receiving also (4.6%) (0.3%) After adjusting baseline variables, increased (adjusted HR: 5.45, 95% confidence interval (CI) 3.61-8.21, p<0.001) 14.34, CI 8.73-23.57, B C). In this cohort, presence AF 1.62; 1.04-2.54, p=0.034) 1.67; 1.13-2.48, p=0.011). further